Endocrine Abstracts

Background: Non-functioning pituitary adenomas (NFPAs) are the most common pituitary macroadenomas with a prevalence of 7-22 per 100,000 population. As they are non-secretory, they tend to present late with visual disturbances, headaches or hormonal deficiencies. Surgery is the main treatment for NFPAs, particularly endoscopic transsphenoidal surgery which can be associated with surgical and endocrine complications.Aims: To compare pre- and post-operativ...

Introduction: There are data reporting an increased risk of cardiovascular and metabolic complications in patients with NCAH. This is frequently attributed to glucocorticoid (over)use. It seems that long-term exposure to increased androgens concentration may also itself lead to diminished insulin sensitivity and increased risk of prediabetes and diabetes.Aim: The aim of the study was to assess the link between NCAH diagnosis and glucose metabolism distur...

Primary hyperparathyroidism (PHP) diagnosis in clinical practice is based on biochemical blood tests. Since a single parathyroid adenoma causes about 85% of cases, the treatment of choice is parathyroidectomy, preceded by imaging studies. Ultrasound and [99mTc]sestamibi scanning can enable adenoma localization. However, the latter method is of higher sensitivity, especially if combined with anatomical imaging. In some cases, the radiotracer uptake in adenoma tissue ...

Introduction: Paragangliomas belong to the neuroendocrine tumours arising from autonomic nervous system. Various localizations, symptoms that can mimic a wide range of diseases and often unpredictable ability to metastasize are the reasons why paragangliomas pose a significant diagnostic challenge. More than one third of paragangliomas is associated with germline mutations –succinate dehydrogenase (SDH) subunit genes are among the most common susceptibility genes. SDHD wa...

Introduction: Paradoxical increase of growth hormone after glucose load (PR) and its clinical significance remain the focus of researchers. Different cut off points for diagnosis of PR are used in the literature. Aim : Our aim was to investigate 3 different definitions of PR and their clinical implications.Material and Methods: We analyzed 116 consecutive patients diagnosed with acromegaly in 2012-2022. We included 89 patients with...

Introduction: Somatotroph Pituitary Neuroendocrine Tumor’s (sPitNET) signal intensity in T2-weighted MR images (SI) was reported as prognostic marker for tumor’s aggressiveness and poor response to 1st generation somatostatin analogs (SSA). Tumors are arbitrary divided into 3 groups: hyperintensive (HYPER), isointensive (ISO) and hypointensive (HYPO). Aim: Our aim was to quantitatively assess SI of sPitNETs and investigate its clinic...

Introduction: Clinical manifestation of hypophysitis depends on presence of hormonal abnormalities and/or enlargement of pituitary structures. Both the diagnosis and treatment still remain challenging. Hormonal replacement is the basic therapy, while steroids are the first-line treatment in case of mass related symptoms. The course of the disease varies from spontaneous remission to atrophy of the pituitary gland.Aim: To characterize and sum up clinical/...

Introduction: Osilodrostat and Metyrapone are two CYP11B1 inhibitors used for the treatment of patients with Cushing syndrome. Despite their common suspected mechanism of action, the comparison of serum steroid profiles determined in HPLC-MS/MS in patients treated by either Osilodrostat or Metyrapone for an ACTH-dependent Cushing syndrome identified higher levels of 11-deoxycortisol and androgens in patients treated by Metyrapone than in those treated by Osilodrostat (F. B...

Post-pituitary surgery hyponatraemia (HN, sodium <135 mmol/l) is relatively common and may result in prolonged hospitalisation. Herein we report a retrospective analysis of our experience in a tertiary institute. We conducted a retrospective case note review of 318 patients (M 54%, F 46%, mean age 58 years) 65.7% non-functioning adenoma (NFA), 10% somatotropinoma, 5% prolactinoma, 11% corticotropinoma (half were clinically silent), 8% craniopharyngioma, an...

Introduction: We present a series of 10 cases of GD presenting with seemingly unrelated symptoms with limited features of thyrotoxicosis, where control of thyroid function tests (TFTs) led to complete normalisation of presenting symptoms. In all cases patients were shown to have Graves disease with thyroid antibodies.Case series review: 1. 82F with symptomatic hypercalcaemia and thymic hyperplasia on CT. Calcium normalised with standard therapy and remai...